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Vitamin B3 as a secret weapon against fatty liver disease: new study is shocking!
Scientists discovered gene miR-93, which worsens liver disease. Vitamin B3 shows promising treatment effects.
Vitamin B3 as a secret weapon against fatty liver disease: new study is shocking!
A new study published in the journal Metabolism has revealed significant advances in the understanding of fatty liver disease. Scientists at the Ulsan National Institute of Science and Technology in South Korea have identified a genetic factor that worsens liver disease. This discovery is particularly significant because an estimated 30% of the global population is affected by this condition, scientifically known as metabolic dysfunction-associated steatotic liver disease (MASLD). Loud Korea BioMed miR-93 levels are noticeably high in patients with fatty liver disease and in animal models.
miR-93 is a microRNA molecule that inhibits genes regulating fatty acid metabolism, such as SIRT1. This inhibition leads to accumulation of fat, inflammation and fibrosis in the liver. In the study, genetic edits revealed that mice deprived of miR-93 showed a significant decrease in fat accumulation in the liver, improved insulin sensitivity, and optimized liver function indicators.
Effect of vitamin B3
The researchers also conducted a review of 150 FDA-approved drugs to find an inhibitor of miR-93. Surprisingly, vitamin B3 (niacin) was identified as the most effective agent. In mice treated with vitamin B3, liver enzymes showed reduced levels of miR-93 and increased SIRT1 activity. This suggests that vitamin B3 restores impaired lipid metabolism and normalizes liver fat levels.
The findings of this study demonstrate the enormous potential of vitamin B3 for the treatment of fatty liver disease. Vitamin B3 is not only considered safe, but has also been used successfully to treat hyperlipidemia. Research continues into how this vitamin can be used in combination therapies to combat fatty liver disease.
Research team and significance of the study
The research team includes renowned scientists such as Professor Choi Jang-hyun from UNIST, Professor Yun Hwa-young from Pusan National University and Professor Park Neung-hwa from Ulsan University Hospital. The work, titled “Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1,” was published on April 12 and offers promising approaches for future treatment strategies.
Overall, the study offers new hope for millions of people struggling with fatty liver disease. Thanks to the identified genetic factors and the effect of vitamin B3, an effective treatment option could be available in the future that could significantly improve the quality of life of those affected.