Vitamin B3 as a secret weapon against fatty liver: New study shocked!

Vitamin B3 as a secret weapon against fatty liver: New study shocked!

A new study, published in the Metabolism journal, has opened significant progress in understanding fatty liver diseases. Scientists of the Ulsan National Institute of Science and Technology in South Korea have identified a genetic factor that worsens liver diseases. This discovery is particularly important, since it is estimated to affect 30% of the global population by this disease, which is scientifically referred to as metabolic dysfunction-associated steatotic liver disease (MASLD). According to korea biomed , the Mir-93 values ​​are striking in patients with fatty liver disease and in animal models.

Mir-93 is a micro-RNA molecule that inhibits the fatty acid metabolism regulating genes, such as Sirt1. This inhibition leads to an accumulation of fat, inflammation and fibrosis in the liver. In the study, genetic arrangements showed that mice that Mir-93 was withdrawn showed a significant decline in fat accumulation in the liver, improved insulin sensitivity and optimized liver function indicators.

effect of vitamin B3

The researchers also carried out an examination of 150 FDA-enclosed medication to find an inhibitor for Mir-93. Surprisingly, vitamin B3 (Niacin) was identified as the most effective means. In mice treated with vitamin B3, the liver values ​​have reduced MIR-93 levels and increased Sirt1 activity. This indicates that vitamin B3 restores the disturbed fat metabolism and normalize the liver fat level.

The knowledge of this study shows the enormous potential of vitamin B3 for the treatment of fatty liver diseases. Vitamin B3 is not only considered safe, but has already been successfully used to treat hyperlipidemia. It is also examined how this vitamin can be used in combination therapies to combat the fatty liver.

research team and meaning of the study

The research team includes well-known scientists such as Professor Choi Jang-Hyun by Unist, Professor Yun Hwa-Young from Pusan ​​National University and Professor Park Nung-HWA from Ulsan University Hospital. Working with the title "Hepatic Mir-93 Promotes the Patthogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease by Suppressing Sirt1 was published on April 12th and offers promising approaches for future treatment strategies.

Overall, the study offers new hope for millions of people who fight fatty liver diseases. Thanks to the identified genetic factors and the effect of vitamin B3, an effective treatment option could be available in the future that could significantly increase the quality of life of those affected.